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Factors Associated with Post-COVID Cardiac Conditions and Potential Prognostic Factors: A Systematic Review
Lidian Franci Batalha Santa Maria1, Josicélia Estrela Tuy Batista2, Virginia Kagure Wachira1
1Center of Tropical Medicine, Faculty of Medicine, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, Brazil.
Insights
COVID-19 vaccination reduces the risk of post-COVID cardiac conditions. However, reinfections increase cardiovascular risks, with some cases persisting long-term, particularly in young children with gastrointestinal symptoms.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- Cardiac conditions are a significant concern among post-COVID conditions.
- Understanding factors influencing these conditions and their outcomes is crucial.
Purpose of the Study:
- To synthesize evidence on factors associated with post-COVID cardiac conditions.
- To determine the frequency of clinical outcomes in affected patients.
- To identify potential prognostic factors for these conditions.
Main Methods:
- A systematic review was conducted.
- Searched databases: EBSCOhost, MEDLINE via PubMed, BVS, and Embase.
- Included studies from 2019 to December 2023, identifying seven eligible articles from 8343 initially found.
Main Results:
- COVID-19 vaccination demonstrated a protective effect, reducing the risk of post-COVID cardiac conditions.
- COVID-19 reinfections were linked to an increased risk of cardiovascular outcomes.
- Most patients recovered, but some experienced persistent symptoms beyond 200 days; four young children with gastrointestinal symptoms did not recover.
Conclusions:
- COVID-19 vaccination regimens effectively reduce the risk of developing post-COVID cardiac conditions.
- Public health policies should promote immunization to prevent SARS-CoV-2 infections and reinfections.
Abstract:
Cardiac conditions are a significant category of post-COVID conditions. The objective of this study was to synthesise the evidence on the factors associated with the development of post-COVID cardiac conditions, the frequency of clinical outcomes in affected patients, and the potential prognostic factors. A systematic review was conducted using the databases EBSCOhost, MEDLINE via PubMed, BVS, and Embase, covering studies from 2019 to December 2023. A total of 8343 articles were identified, and seven met the eligibility criteria for data extraction. The protective effect of vaccination stood out among the associated factors, showing a reduced risk of developing post-COVID cardiac conditions. Conversely, COVID-19 reinfections were associated with an increased risk of cardiovascular outcomes. Regarding the main outcomes in these patients, most recovered, although some cases persisted beyond 200 days of follow-up. The study included in the analysis of prognostic factors reported that the four children who did not recover by the end of the study were between two and five years old and had gastrointestinal symptoms during the illness. The COVID-19 vaccination regimen reduces the risk of developing post-COVID cardiac conditions. Public health policies promoting immunisation should be encouraged to prevent SARS-CoV-2 infections and reinfections.
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