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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Topical Dopamine Application on Form-Deprivation Myopia in Rabbits.

Dong Hyun Kim1, Jeong-Min Hwang1, Hee Kyung Yang1

  • 1Department of Ophthalmology, College of Medicine, Seoul National University, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.

Life (Basel, Switzerland)
|March 27, 2025
PubMed
Summary
This summary is machine-generated.

Topical dopamine effectively inhibited form deprivation myopia in rabbits by reducing axial elongation. This treatment showed significant efficacy and safety, suggesting potential for myopia management.

Keywords:
form deprivation myopiarabbit myopiatopical dopamine

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Animal Models

Background:

  • Myopia, a global vision impairment, necessitates effective interventions.
  • Form deprivation (FD) myopia is a common animal model for studying myopia progression.
  • Investigating novel therapeutic agents for myopia control is crucial.

Purpose of the Study:

  • To evaluate the efficacy of topical dopamine in inhibiting FD myopia in a rabbit model.
  • To assess the safety profile of topical dopamine administration on ocular tissues.

Main Methods:

  • Neonatal New Zealand white rabbits were used, with FD myopia induced in one eye.
  • The treatment group received topical 4% dopamine, while the control group received saline daily for four weeks.
  • Axial length was measured, and histological analysis assessed retinal safety.

Main Results:

  • Dopamine treatment significantly reduced axial elongation in FD eyes (15.07 ± 0.34 mm) compared to controls (15.63 ± 0.33 mm, p=0.015).
  • Histological examination revealed no retinal structural alterations or apoptosis, indicating safety.
  • Topical dopamine demonstrated significant efficacy in inhibiting myopia progression.

Conclusions:

  • Topical dopamine is a promising therapeutic strategy for controlling myopia progression.
  • The study supports dopamine's potential in managing myopia without ocular toxicity.
  • Further clinical research is warranted to explore dopamine's application in human myopia.