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Updated: May 20, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Association of Voltage-Gated Potassium Channel Polymorphisms with the Risk and Prognosis of Epilepsy in the Saudi
Mansour A Alghamdi1,2, Laith N Al-Eitan3, Mansour Y Otaif4
1Department of Anatomy, College of Medicine, King Khalid University, Abha 62529, Saudi Arabia.
Abstract:
Background and Objectives: Epilepsy, known as an unprovoked seizure, arises from the human brain. Genetics plays a fundamental role in the development and progression of the disorder. This study aimed to investigate the influence of voltage-gated K+ channels on the risk of epilepsy. Materials and Methods: Several genetic variants were examined using PCR sequencing. This case-control study was conducted on 296 individuals who were diagnosed with epilepsy, in addition to 293 healthy participants. Results: This study revealed that within KCNAB1, both rs3755631 and rs4679773 are correlated with epilepsy, and the p-values = 0.04 for both allelic associations. In addition, regarding the KCNJ10 gene, we found that rs2820585, rs946420, rs1186679, rs61822012, and rs1186685 were significantly correlated with epilepsy risk (p-values = 0.034, 0.045, 0.021, 0.048, and 0.018), respectively. Conclusions: From the current study, we conclude that voltage-gated potassium channels can impact epilepsy risk and can also interfere with the prognosis of epilepsy.
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