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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

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Related Experiment Video

Updated: May 13, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Candida auris: A Continuing Threat.

Ashish Bhargava1,2, Katherine Klamer1, Mamta Sharma1

  • 1Thomas Mackey Center of Infectious Diseases, Henry Ford Health-St. John Hospital, Detroit, MI 48236, USA.

Microorganisms
|March 27, 2025
PubMed
Summary

Candida auris, a critical fungal pathogen, exhibits antifungal resistance and environmental persistence, leading to high mortality rates. This review summarizes its current status to guide future research and interventions.

Keywords:
Candida aurisantifungal resistancenosocomial transmissionpathogenic fungi

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Last Updated: May 13, 2026

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Public Health

Background:

  • Candida auris is a critical-priority fungal pathogen identified by the WHO.
  • It demonstrates variable resistance to antifungal medications.
  • Genomic analysis reveals multiple clades appearing globally.

Purpose of the Study:

  • To review the current understanding of Candida auris.
  • To highlight factors contributing to its success.
  • To provide guidance for future research and clinical management.

Main Methods:

  • Literature review of existing studies on Candida auris.
  • Genomic analysis of identified clades.
  • Epidemiological data compilation.

Main Results:

  • Candida auris exhibits significant antifungal resistance.
  • It possesses traits for environmental colonization and persistence.
  • Thermotolerance contributes to its survival and spread.
  • High mortality rates are associated with C. auris infections, particularly in vulnerable patients.

Conclusions:

  • Candida auris poses a significant global health threat due to its resistance and adaptability.
  • Understanding its characteristics is crucial for effective control strategies.
  • Further research is needed to combat this emerging pathogen.