Effects of a Supervised-As-Needed Home Exercise Program on Scoliosis and Motor Function in Rett Syndrome: A...

Area of Science:

• Neurology
• Orthopedics
• Rehabilitation Medicine

Background:

• Scoliosis is a common complication in Rett syndrome (RTT), frequently requiring surgical intervention.
• Early intervention is crucial for managing scoliosis and maintaining functional abilities in individuals with RTT.

Purpose of the Study:

• To evaluate the effectiveness of a 10-month individualized home exercise program (HEP) on scoliosis progression in girls with RTT.
• To assess the impact of the HEP on gross motor function in the same population.

Main Methods:

• A multiple-baseline single-case design (AABA) involving 20 girls (aged 6-16) with RTT.
• Daily, remotely supervised HEP focusing on posture and physical activity for at least one hour.
• Primary outcome: Cobb angle change (scoliosis progression) via spinal radiographs; Secondary outcome: Gross motor function assessment.

Main Results:

• The HEP did not significantly reduce the overall rate of scoliosis progression.
• Individual participants showed varied responses, with three experiencing scoliosis reduction.
• Significant improvements were noted in gross motor functions, including standing, walking, and stair climbing.

Conclusions:

• The implemented HEP did not demonstrate a significant effect on overall scoliosis progression in individuals with RTT.
• The HEP led to significant improvements in gross motor function.
• Further research with larger sample sizes is warranted to validate exercise interventions for RTT.