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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Hemoperfusion Using the Oxiris Membrane in Septic Shock Patients with Preserved Kidney Function: A Case Series
Darja Smirnova1,2, Rihards Serzans2, Mara Klibus1,2
1Department of Anesthesiology, Intensive Care and Clinical Simulations, Riga Stradiņš University, LV-1007 Riga, Latvia.
Journal of Clinical Medicine
|March 27, 2025
Summary
Hemoperfusion using the Oxiris membrane stabilized patients with septic shock by reducing inflammatory markers and endotoxin levels. This innovative treatment shows promise for early immune modulation in sepsis before kidney damage occurs.
Area of Science:
- Critical Care Medicine
- Nephrology
- Immunology
Background:
- Sepsis, a life-threatening organ dysfunction from infection, involves endotoxin and cytokine overload.
- The Oxiris membrane can adsorb endotoxins and cytokines.
- This study explores Oxiris hemoperfusion in septic shock patients with preserved renal function.
Observation:
- Three adult patients with refractory septic shock received 12-hour Oxiris hemoperfusion.
- Hemodynamic parameters, inflammatory biomarkers, and endotoxin levels were monitored.
- Patients had preserved renal function and high vasopressor needs.
Findings:
- Hemodynamic stabilization occurred, reducing norepinephrine support.
- Significant decreases were observed in interleukin-6, procalcitonin, and C-reactive protein.
- Endotoxin levels decreased in two patients, with no adverse events reported.
Implications:
- Oxiris hemoperfusion effectively reduced vasopressor support and inflammatory markers in septic shock.
- This method may offer early immune modulation in sepsis prior to renal dysfunction.
- Larger studies are needed to confirm efficacy and optimize treatment protocols.
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