Development and Evaluation of Anti-Pollution Film-Forming Facial Spray Containing Coffee Cherry Pulp Extract.

Area of Science:

• Cosmeceutical science
• Dermatology
• Materials science

Background:

• Environmental pollution poses risks to skin health.
• Coffee cherry pulp extract contains bioactive compounds with potential skincare benefits.
• Developing effective delivery systems for cosmeceuticals is crucial.

Purpose of the Study:

• To develop and evaluate an anti-pollution film-forming spray (FFS) using coffee cherry pulp extract (FFS-CCS).
• To assess the physical properties, stability, skin penetration, and clinical efficacy of the FFS-CCS.
• To investigate the potential of FFS-CCS as a sustainable cosmeceutical for anti-aging and environmental protection.

Main Methods:

• Formulation of FFS-CCS using polymers (PVP K90) and a ternary solvent system.
• Characterization of physical properties, including film formation, viscosity, and sprayability.
• Stability testing, skin penetration studies using Franz diffusion cells, and a 60-day clinical trial with 42 participants.

Main Results:

• The FFS1-CCS formulation enhanced solubility, stability, and bioavailability of coffee cherry extract bioactives.
• Physical characterization confirmed optimal film properties and sprayability.
• Clinical evaluation showed significant improvements in skin hydration, tone, and wrinkle reduction, with minimal systemic absorption.

Conclusions:

• FFS-CCS formulation with PVP K90 improved stability, bioavailability, and skin retention of coffee cherry extract.
• The FFS-CCS demonstrated significant benefits for skin hydration, wrinkle reduction, and skin tone.
• Coffee cherry pulp extract shows promise as a sustainable cosmeceutical ingredient for anti-aging and pollution defense.