Ciprofloxacin-Loaded Spray-Dried Lactose Particles: Formulation Optimization and Antibacterial Efficacy

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Bacterial infections in the oral cavity and outer ear necessitate advanced drug delivery systems.
• Targeted antibiotic formulations are crucial for combating localized infections.

Purpose of the Study:

• To develop and characterize drug-loaded lactose microparticles for antibiotic delivery.
• To create effective formulations for treating oral and outer ear bacterial infections.

Main Methods:

• Lactose microparticles were produced using spray drying.
• Particles were optimized for ciprofloxacin loading and characterized for physicochemical properties, drug release, and antibacterial efficacy.

Main Results:

• Spherical lactose microparticles achieved high ciprofloxacin loading (1.1-52.9% w/w).
• Rapid drug release (70-81% in 5 h) and concentration-dependent antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa were observed.
• Bacterial growth was inhibited for over 24 hours at minimum inhibitory concentrations.

Conclusions:

• Spray-dried ciprofloxacin-loaded lactose microparticles offer an efficient localized antibacterial treatment strategy.
• These particles present a promising solution for managing bacterial infections in the oral cavity and outer ear.