Bioactive Substances and Skin Health: An Integrative Review from a Pharmacy and Nutrition Perspective

Area of Science:

• Dermatology and Cosmetology
• Pharmacology
• Nutritional Science

Background:

• Skin health is influenced by lifestyle, nutrition, and skincare.
• Bioactive substances from plant and marine sources are crucial for skin health.
• Understanding these compounds' effects is vital for dermatological and cosmetic advancements.

Purpose of the Study:

• To compile and synthesize the main evidence on the relationship between bioactive substances and skin health.
• To identify and categorize key bioactive compounds relevant to skin well-being.
• To review their potential applications in dermatology and cosmetics.

Main Methods:

• An integrative review methodology was employed, adhering to PRISMA (2020) guidelines.
• Extensive literature searches were conducted using thirteen distinct search equations.
• A rigorous screening and selection process resulted in the compilation of 95 relevant references.

Main Results:

• Bioactive compounds were classified into food-derived components, nutraceuticals, symbiotics, marine-origin substances, and plant extracts.
• Evidence indicates significant benefits of these compounds for skin health.
• Key findings highlight anti-inflammatory and antimicrobial effects.

Conclusions:

• Bioactive compounds, including dietary nutrients, plant extracts, and marine metabolites, show promise for improving skin health.
• These substances demonstrate anti-inflammatory and antimicrobial activities.
• They are relevant as active principles for cosmetic formulations and managing skin conditions.