Leaf-Like Nanostructures Self-Assembled by Silver-Coordinated Photosensitizers as Collaborative Antimicrobial Agents
Xiaoxue Fan1,2, Ran An1,2, Shibo Lv2
1Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jiyan Road, Huaiyin District, Jinan, 250117, China.
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This research introduces an innovative approach to addressing bacterial infections in wounds using leaflike nanostructures, which are self-assembled via coordination between the photosensitizer phenylcarbazole-[1,2,5]thiadiazolo[3,4-f]benzotriazole-m-pyridine and silver ions. These nanostructures combine photosensitizer-generated singlet oxygen with silver's antibacterial effects, synergistically promoting wound healing. When incorporated into a Carbopol 941 hydrogel matrix, these nanostructures achieve near-total bacterial eradication (0.04% survival) while accelerating wound healing and tissue regeneration in a mouse model. This dual-functional mechanism allows the nanostructures to perform exceptionally well against Gram-positive and Gram-negative bacteria, even in biofilm environments, where conventional strategies solely on individual components often fail.
