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Related Experiment Video

Updated: May 20, 2025

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
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Relationship Between Brain-Derived Neurotrophic Factor and Cognitive Function in Methamphetamine-Dependent Patients.

Hwallip Bae1, Sung-Doo Won2, Jiyoun Kim3,4

  • 1Department of Psychiatry, National Medical Center, Seoul, Republic of Korea.

Psychiatry Investigation
|March 27, 2025
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Summary

Chronic methamphetamine (METH) use impairs cognitive function. This study found that brain-derived neurotrophic factor (BDNF) levels correlate with executive function, specifically the trail-making test, in METH-dependent patients.

Keywords:
Brain-derived neurotrophic factor.Cognitive functionMethamphetamine dependence

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Toxicology

Background:

  • Methamphetamine (METH) is a neurotoxic drug associated with neurodegeneration and cognitive deficits in dependent individuals.
  • Brain-derived neurotrophic factor (BDNF) is a key regulator of neuroplasticity and neuronal survival, potentially reflecting neuroadaptive changes in response to METH use.

Purpose of the Study:

  • To investigate the relationship between cognitive function and BDNF levels in patients with METH dependence.
  • To characterize the impact of METH dependence on cognitive performance and its association with neurotrophic factors.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum BDNF levels in 38 METH-dependent patients.
  • Cognitive function was assessed using the Consortium to Establish a Registry for Alzheimer's Disease-Korean version (CERAD-K).
  • Statistical analyses were performed to compare CERAD-K subtest scores with BDNF levels.

Main Results:

  • METH-dependent patients generally performed adequately on most CERAD-K cognitive tests.
  • A significant correlation was observed specifically between BDNF levels and performance on the trail-making test part B, an indicator of executive function.

Conclusions:

  • The trail-making test is a sensitive measure for evaluating executive function deficits in METH dependence.
  • BDNF may serve as a crucial biomarker for identifying neurocognitive functional decline associated with chronic METH use.