Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radiation therapy for thyroid eye diseases.

T Hurbli, D H Char, J Harris

    American Journal of Ophthalmology
    |June 15, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Iris ring melanoma: fine needle biopsy.

    The British journal of ophthalmology·2006
    Same author

    20 MHz high frequency ultrasound assessment of scleral and intraocular conjunctival squamous cell carcinoma.

    The British journal of ophthalmology·2002
    Same author

    Uveal tumour resection.

    The British journal of ophthalmology·2001
    Same author

    Early wound dehiscence with use of hydroxyapatite orbital implant covered with calf pericardium.

    The British journal of ophthalmology·2001
    Same author

    Objective evaluation of improvement in optic neuropathy following radiation therapy for thyroid eye disease, by S. Rush, J. M. Winterkorn, and R. Zak. Int J. Radiat Oncol Biol. Phys 47:191-4, 2000.

    Survey of ophthalmology·2001
    Same author

    Amelanotic corneal melanoma after a blast injury.

    American journal of ophthalmology·2001

    Fractionated photon irradiation effectively treated thyroid ophthalmopathy in 62 patients. Early disease duration (<6 months) correlated with better outcomes for thyroid eye disease, including motility and optic neuropathy.

    Area of Science:

    • Ophthalmology
    • Endocrinology
    • Radiation Oncology

    Background:

    • Thyroid ophthalmopathy, also known as Graves' ophthalmopathy, is an autoimmune condition affecting the eyes.
    • It can lead to significant visual impairment, including motility problems and optic neuropathy.
    • Current treatments aim to reduce inflammation and prevent vision loss.

    Purpose of the Study:

    • To evaluate the efficacy of fractionated photon irradiation in treating thyroid ophthalmopathy.
    • To assess the impact of treatment on ocular motility and thyroid optic neuropathy.
    • To determine if disease duration influences treatment response.

    Main Methods:

    • Sixty-two patients diagnosed with thyroid ophthalmopathy were enrolled.
    • Treatment involved approximately 20 Gy of fractionated photon irradiation.

    Related Experiment Videos

  • Patient outcomes were assessed based on improvements in motility and optic neuropathy.

    • Main Results:

    • Eight of 14 patients (57%) with motility issues showed improvement post-irradiation.
    • Ten of 14 patients (71%) with thyroid optic neuropathy improved or stabilized.
    • Four patients experienced recurrence of optic neuropathy within five months.
    • Patients with disease duration less than six months generally responded better.

    Conclusions:

    • Fractionated photon irradiation is a viable treatment option for thyroid ophthalmopathy.
    • Early intervention in thyroid eye disease may lead to superior treatment outcomes.
    • Further research is warranted to optimize radiation protocols and patient selection.