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Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production
Published on: November 17, 2023
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Association between orchiectomy and asthma: Insights from 2 population-based cohorts
Battoul Fakhry1, Celine Chedraoui1, Joelle Sleiman1
1Lerner Research Institute and Respiratory Institute, Cleveland Clinic, Cleveland, Ohio.
The Journal of Allergy and Clinical Immunology. Global
|March 27, 2025
Summary
Orchiectomy may increase asthma risk due to hormonal changes. This study found a significantly higher likelihood of asthma in men who underwent orchiectomy in two large databases.
Area of Science:
- Endocrinology
- Pulmonology
- Health Informatics
Background:
- Orchiectomy, a procedure leading to hypogonadism, is hypothesized to elevate asthma risk.
- Androgen deficiency resulting from orchiectomy may play a role in asthma development.
Purpose of the Study:
- To investigate the potential association between orchiectomy and the subsequent risk of asthma diagnosis.
- To quantify the risk of asthma in individuals who have undergone orchiectomy.
Main Methods:
- Retrospective analysis of two large real-world databases: IBM-Explorys (1999-2016) and TriNetX (May 2024).
- Inclusion criteria: Men aged 18 years or older.
- Multivariable logistic regression adjusted for age and BMI was used to assess asthma risk in orchiectomy versus non-orchiectomy groups.
Main Results:
- The IBM-Explorys database showed a 2-fold increased odds of asthma in the orchiectomy group (aOR=2.03, P<.001).
- The TriNetX database confirmed a higher asthma risk in the orchiectomy group (aOR=1.61, P<.001).
- Findings were consistent across both independent datasets.
Conclusions:
- Individuals who have undergone orchiectomy face an elevated risk of developing asthma.
- Further research is warranted to elucidate the underlying biological mechanisms connecting orchiectomy and asthma.
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