Association between triglyceride glucose-waist height ratio and stroke: a population-based study
Fangyuan Xu1, Xingxing Su2, Fan Dai1
1The First Clinical Medical School, Anhui University of Chinese Medicine, Hefei, China.
Frontiers in Endocrinology
|March 27, 2025
Summary
The triglyceride glucose-waist height ratio (TyG-WHtR) is linked to a higher stroke risk. Elevated TyG-WHtR may help predict stroke, aiding in early prevention and intervention strategies.
Area of Science:
- Cardiovascular Health
- Metabolic Syndrome Research
- Public Health Epidemiology
Background:
- Stroke is a major global health concern.
- The triglyceride glucose-waist height ratio (TyG-WHtR) shows promise in assessing health risks.
- Limited research exists on the specific link between TyG-WHtR and stroke incidence.
Purpose of the Study:
- To investigate the association between TyG-WHtR levels and stroke.
- To evaluate TyG-WHtR as a potential biomarker for stroke risk.
- To analyze data from the National Health and Nutrition Examination Survey (NHANES).
Main Methods:
- Analysis of 8,757 participants from NHANES (2011-2018).
- Multivariable logistic regression and smooth curve fitting to assess the TyG-WHtR-stroke relationship.
- Subgroup, sensitivity, and ROC curve analyses to confirm findings and compare predictive values.
Main Results:
- A positive association was found between higher TyG-WHtR and increased stroke occurrence (OR: 1.26).
- Each unit increase in TyG-WHtR correlated with a 26% higher stroke likelihood.
- TyG-WHtR demonstrated superior predictive capability over the TyG index.
Conclusions:
- Elevated TyG-WHtR levels are associated with increased stroke prevalence.
- TyG-WHtR may serve as a valuable predictive tool for stroke risk.
- Findings support TyG-WHtR's potential role in clinical stroke prevention and early intervention.
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