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Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2/HO-1 pathway
Tianwang Guan1,2, Zhenxing Lu2,3, Rundong Tai2,3,4
1Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, Cancer Center, The 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong, 523059, China.
Abstract:
Diabetes and chemotherapy frequently give rise to severe cardiovascular complications, including chemotherapy-induced cardiotoxicity and diabetes-associated vascular remodeling. Nevertheless, the precise epidemiological features of these cardiovascular ailments remain incompletely elucidated, resulting in a dearth of effective therapeutic strategies in clinical settings. To tackle this intricate challenge, we have delved extensively into database resources, conducted comprehensive analyses of pertinent epidemiological data, and designed silicified curcumin (Si/Cur) microspheres as a novel therapeutic approach for cardiovascular diseases. By harnessing the alkaline microenvironment generated by silicon (Si), Si/Cur markedly elevates the bioavailability of curcumin (Cur). Further investigations have elucidated that Si/Cur exerts its therapeutic actions primarily via the Nrf2/HO-1 signaling pathway, effectively suppressing vascular remodeling and mitigating myocardial injury, thus disrupting the vicious cycle of persistent cardiovascular damage. In conclusion, this study integrates clinical cohort research to dissect epidemiological characteristics, directs the design and application of biomaterials, and paves the way for a novel and efficacious therapeutic avenue for the management of cardiovascular diseases.
Insights
This study reveals silicified curcumin (Si/Cur) microspheres as a novel treatment for cardiovascular diseases linked to diabetes and chemotherapy. Si/Cur enhances curcumin bioavailability and protects against vascular remodeling and heart damage.
Area of Science:
- Biomaterials Science
- Cardiovascular Medicine
- Pharmacology
Background:
- Diabetes and chemotherapy induce severe cardiovascular complications like cardiotoxicity and vascular remodeling.
- Current understanding of epidemiological features and effective treatments for these conditions is limited.
Purpose of the Study:
- To investigate epidemiological characteristics of cardiovascular diseases associated with diabetes and chemotherapy.
- To develop and evaluate silicified curcumin (Si/Cur) microspheres as a novel therapeutic agent for cardiovascular diseases.
Main Methods:
- Comprehensive analysis of epidemiological data from database resources.
- Design and synthesis of silicified curcumin (Si/Cur) microspheres.
- Investigation of Si/Cur's mechanism of action, focusing on the Nrf2/HO-1 signaling pathway.
Main Results:
- Silicified curcumin (Si/Cur) microspheres significantly enhance curcumin bioavailability.
- Si/Cur effectively suppresses vascular remodeling and mitigates myocardial injury.
- The therapeutic effects are mediated through the Nrf2/HO-1 signaling pathway, disrupting cardiovascular damage cycles.
Conclusions:
- This study provides crucial epidemiological insights into diabetes- and chemotherapy-related cardiovascular diseases.
- Silicified curcumin (Si/Cur) microspheres represent a promising biomaterial-based therapeutic strategy.
- The findings open a new avenue for managing cardiovascular diseases by targeting specific molecular pathways.
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