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Related Concept Videos

Nerve Supply of the GI Tract01:27

Nerve Supply of the GI Tract

813
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
813
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

273
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
273
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

35
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
35
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

206
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
206
Neural Regulation01:37

Neural Regulation

39.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.0K

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Related Experiment Video

Updated: May 20, 2025

In Situ Ca2+ Imaging of the Enteric Nervous System
11:26

In Situ Ca2+ Imaging of the Enteric Nervous System

Published on: January 29, 2015

17.1K

Imaging the enteric nervous system.

Doriane Hazart1,2, Marwa Moulzir1, Brigitte Delhomme1

  • 1Université Paris Cité, CNRS, Saints-Pères Paris Institute for the Neurosciences, Paris, France.

Frontiers in Neuroanatomy
|March 27, 2025
PubMed
Summary
This summary is machine-generated.

The enteric nervous system (ENS), crucial for digestion and linked to neurological disorders, is increasingly studied using advanced 3-D imaging. New techniques reveal its complex structure and function, aiding research into gastrointestinal and CNS diseases.

Keywords:
3-D imagingclearing methodhistological methodin-vivo imagingintestinewhole-mount preparation technique

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Related Experiment Videos

Last Updated: May 20, 2025

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Area of Science:

  • Neurobiology
  • Gastroenterology
  • Microscopy

Background:

  • The enteric nervous system (ENS) plays a vital role in digestion and is implicated in various gastrointestinal and central nervous system (CNS) disorders.
  • Understanding the ENS is crucial, yet its complex structure and function are less explored than the CNS.

Purpose of the Study:

  • To review methodologies for studying the ENS's 3-D structure and function, from historical techniques to recent advancements.
  • To highlight how new imaging technologies are enhancing our comprehension of ENS organization and its role in disease.

Main Methods:

  • Traditional histological sectioning and imaging.
  • Advanced 3-D imaging techniques: spinning-disk confocal, 2-photon, light-sheet microscopy, and tissue clearing.
  • In-vivo functional imaging: 2-photon, confocal microscopy, and confocal laser endomicroscopy with calcium imaging.

Main Results:

  • 3-D imaging and tissue clearing reveal detailed ENS cellular architecture and vessel interactions.
  • Advanced methods improve understanding of ENS pathologies like inflammatory bowel disease, Hirschsprung's disease, Parkinson's, and Alzheimer's diseases.
  • In-vivo functional imaging enables real-time observation of enteric neuronal and glial activity.

Conclusions:

  • Recent advancements in 3-D and in-vivo imaging are revolutionizing ENS research.
  • These techniques offer deeper insights into ENS function and its involvement in neurological and gastrointestinal diseases.
  • Future applications promise improved diagnostics and therapeutics for ENS-related conditions.