Related Experiment Video
Updated: May 20, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
Burden of cancer attributable to exogenous hormone use in Japan in 2015
Mayo Hirabayashi1, Chisato Nagata2, Sarah Krull Abe1
1Division of Prevention, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Abstract:
Exogenous female hormone use has not been as popular in Japan as in western populations. Here, we estimated the population-attributable fraction (PAF) of cancers in Japan in 2015 attributed to exogenous female hormone use. We used the most recent prevalence data for oral contraceptives (OC) and hormone replacement therapy (HRT), available from a large-scale population-based cohort study started in 2011-2016. For the purpose of this study, optimal usage of exogenous hormones was considered to be none. PAF was calculated for each age group using a standard formula. Overall, a negligible fraction, 0.4% of cancer incidence and 0.2% of cancer mortality in Japanese women was attributable to exogenous hormone use (OC use and HRT), and 0.2% of cancer incidence and 0.1% of cancer mortality overall when both sexes combined. The relatively low prevalence of exogenous hormone use in Japan compared to Western countries may explain the low fraction of cancer attributable to exogenous hormones among Japanese women.
More Related Videos
06:18An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
07:08Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
Published on: August 31, 2022
Related Concept Videos
Cancer Prevention
Some...
Hormonal Regulation
Mitogens and the Cell Cycle
Gonadal and Placental Hormones
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
Regulation of Hormone Secretion
Humoral...
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...