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Picoinjection of Microfluidic Drops Without Metal Electrodes

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Anticoagulation colloidal microrobots based on heparin-mimicking polymers.

Huanhuan Wang¹, Huaguang Wang¹, Xiaoli Liu¹

¹College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

Journal of Colloid and Interface Science

|March 27, 2025

Summary

A novel microrobot platform offers efficient anticoagulation by mimicking heparin to prevent blood clotting and promote healing. Its self-propulsion enables targeted delivery for cardiovascular disease treatment.

Keywords:

Anticoagulation Colloidal microrobots Heparin-mimicking polymers Self-propulsion Thermophoresis

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Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Cardiovascular diseases and mortality are significantly driven by blood coagulation.
Effective anticoagulant strategies are crucial for public health.
Current treatments may have limitations necessitating novel approaches.

Purpose of the Study:

To develop a novel, efficient, and dynamic anticoagulant platform.
To engineer a biofunctionalized microrobot for targeted anticoagulation.
To investigate the therapeutic potential of self-propelled colloidal devices.

Main Methods:

Fabrication of a Janus colloidal sphere microrobot with heparin-mimicking polymers and gold.
Utilizing biocompatible near-infrared (NIR) irradiation for self-propulsion without chemical fuel.
Evaluating the microrobot's anticoagulant properties, endothelial cell effects, and smooth muscle cell proliferation inhibition.

Main Results:

The microrobot demonstrated effective anticoagulation by mimicking heparin.
NIR irradiation enabled fuel-free self-propulsion for targeted delivery.
The microrobot promoted endothelial cell growth and inhibited smooth muscle cell proliferation.
The microrobot successfully traveled long distances within blood vessels for targeted anticoagulation.

Conclusions:

A novel biofunctionalized microrobot platform offers a promising approach for anticoagulation.
Self-propelled colloidal devices represent an innovative strategy for cardiovascular disease management.
This technology opens new avenues for developing advanced bio-inspired medical devices.