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Related Experiment Videos

CyFidb: A Molecular Atlas for Cystic Fibrosis.

Catarina Pereira1, Margarida D Amaral1, Andre O Falcao1

  • 1BioISI-Biosystems Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|March 27, 2025
PubMed
Summary

Cystic fibrosis (CF) is a genetic disease caused by CFTR gene variants. A new database, CyFidb, consolidates CF-related data, including protein interactions and gene expression, for easier research access.

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Area of Science:

  • Genetics and Molecular Biology
  • Bioinformatics
  • Disease Research

Background:

  • Cystic fibrosis (CF) is a genetic disorder caused by over 2,100 variants in the CF Transmembrane Conductance Regulator (CFTR) gene.
  • CFTR protein functions as an anion channel in epithelial cells.
  • Existing CF-related data is fragmented across multiple resources, hindering comprehensive analysis.

Purpose of the Study:

  • To develop a centralized, accessible resource for cystic fibrosis research.
  • To consolidate scattered CF-related information into a single repository named CyFidb.

Main Methods:

  • Manual curation of 407 scientific articles.
  • Inclusion of studies on CFTR variants, various conditions, drug treatments, and cell/tissue types.
Keywords:
BioinformaticsCFTRCystic fibrosisDatabaseSystems-biologyrepository

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Main Results:

  • CyFidb organizes information into three levels: protein-protein interactions, gene expression, and functional studies.
  • Users can search and extract specific data relevant to CFTR variants and their biological context.

Conclusions:

  • CyFidb is an open-access, continuously updated resource for curated CFTR variant data.
  • The platform aims to streamline research by providing a unified source of biological information for CF.