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Factor H-related 2 levels dictate FHR dimer composition.

Bert R J Veuskens1,2, Mieke C Brouwer1, Gerard van Mierlo1

  • 1Sanquin Research and Landsteiner Laboratory of the Amsterdam University Medical Centers, University of Amsterdam, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands.

Scientific Reports
|March 28, 2025
PubMed
Summary

Factor H-related proteins 1 and 2 form dimers, influencing complement regulation. This study developed a new ELISA to quantify Factor H-related protein 2 homodimers, revealing insights into dimer distribution and disease associations.

Keywords:
Complement systemDimerizationFHR-1FHR-2

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