Related Experiment Video
Updated: Jul 22, 2026

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
Published on: September 4, 2017
Automated system for establishing standard radiation dose-response curves and dose estimation for the Korean
Su Jung Oh1, Min Ho Jeong2, Yeong-Rok Kang1
1Dongnam Institute of Radiological and Medical Sciences (DIRAMS), 40 Jwadong-gil, Jangan-eup, Gijang-gun, Busan, 46033, Republic of Korea.
Abstract:
Biological dosimetry is crucial for estimating the doses from biological samples and guiding medical interventions for accidental radiation exposure. This study aimed to derive rapid and precise dose estimates using a dicentric chromosome assay. To address the challenges of manual scoring of dicentric chromosomes, we upgraded an automatic system aimed at enhancing the precision of dicentric chromosome detection while reducing the need for human intervention. We collected blood from 30 individuals aged 20-67 years to create 30 dose-response curves aiming to investigate the differences in responses among individuals. To validate dose-estimate accuracy within a 95% confidence interval, blinded samples were categorized into three groups according to the radiation dose as follows: ≥2, ≤ 1, and 0.1 Gy. When scoring dicentric chromosomes without human review and constructing a dose-response curve, individual differences were observed. For doses ≤ 1 Gy, the standard root formula was effective; conversely, for doses ≥ 2 Gy, the regression deep neural network proved to be more ac-curate. Our developed program allowed for the rapid analysis of a large volume of dicentric chromosome images.
Related Concept Videos
Dose-Response Relationship: Overview
Dosage Regimens: Designs and Approaches
Dosage Regimens: Partial Pharmacokinetic Parameters
Dosage Regimen Designs: Nomograms and Tabulations
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Dose Response Curve: Conventional Versus Nonmonotonic

