Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Governing the Cross-Species Virulence of Shiga Toxin-Producing <i>Escherichia coli</i>.

Pathogens (Basel, Switzerland)·2026
Same author

Sex Alters Hypoxic Responses in <i>Caenorhabditis elegans</i>.

microPublication biology·2026
Same author

Phosphodiesterases Regulate <i>C. elegans</i> Bitter Taste Avoidance.

microPublication biology·2025
Same author

Wild strains reveal natural variation in C. elegans avoidance behaviors.

G3 (Bethesda, Md.)·2025
Same author

Mitochondrial membrane potential and compartmentalized signaling: Calcium, ROS, and beyond.

Redox biology·2025
Same author

Microbiota-Influenced Toxicological Responses in <i>Caenorhabditis elegans</i> Exposed to Strawberry and Menthol E-Liquids.

microPublication biology·2025
Same journal

Tissue MicroRNAs in Arrhythmogenic Cardiomyopathy: A Systematic Review of Studies in Human Myocardium and Animal Models with Implications for Post-Mortem Molecular Diagnostics.

Genes·2026
Same journal

Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.

Genes·2026
Same journal

Generative AI and Language Models in Human Genetics and Health: From Variant Interpretation to Clinical Decision Support.

Genes·2026
Same journal

Familial White-Sutton Syndrome Caused by a Pathogenic POGZ p.Arg508* Variant: Intrafamilial Variability from Childhood to Adulthood.

Genes·2026
Same journal

Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia.

Genes·2026
Same journal

THBS1 as a Key Regulator of Myoblasts: Validation of Its Inhibitory Roles in Skeletal Muscle Development.

Genes·2026
See all related articles

Related Experiment Video

Updated: May 7, 2026

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay
06:45

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay

Published on: July 26, 2017

An Extensive Gap Junction Neural Network Modulates Caenorhabditis elegans Aversive Behavior.

Savannah E Sojka1, Meredith J Ezak1, Emily A Polk1

  • 1Ferkey Laboratory, Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

Genes
|March 28, 2025
PubMed
Summary
This summary is machine-generated.

Six innexins modulate Caenorhabditis elegans

Keywords:
C. elegansavoidancebehaviorcGMPchemosensationgap junctioninnexinnociception

More Related Videos

Calcium Imaging in Freely Behaving Caenorhabditis elegans with Well-Controlled, Nonlocalized Vibration
06:50

Calcium Imaging in Freely Behaving Caenorhabditis elegans with Well-Controlled, Nonlocalized Vibration

Published on: April 29, 2021

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

Related Experiment Videos

Last Updated: May 7, 2026

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay
06:45

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay

Published on: July 26, 2017

Calcium Imaging in Freely Behaving Caenorhabditis elegans with Well-Controlled, Nonlocalized Vibration
06:50

Calcium Imaging in Freely Behaving Caenorhabditis elegans with Well-Controlled, Nonlocalized Vibration

Published on: April 29, 2021

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

Area of Science:

  • Neuroscience
  • Genetics
  • Behavioral Biology

Background:

  • Caenorhabditis elegans utilize sensory cues for survival.
  • ASH neurons detect aversive signals, triggering avoidance behaviors.
  • Gap junctions regulate ASH neuron sensitivity to stimuli.

Purpose of the Study:

  • Identify gap junction proteins (innexins) modulating ASH-mediated nociceptive responses.
  • Investigate the roles of specific innexins in behavioral regulation.

Main Methods:

  • Utilized genetic mutants in C. elegans.
  • Employed cell-selective rescue and knockdown experiments.
  • Characterized innexin function in nociceptive behavioral modulation.

Main Results:

  • Identified six C. elegans innexins (INX-7, INX-15, INX-16, INX-17, UNC-7, UNC-9) with regulatory roles.
  • Demonstrated overlapping and distinct functions among these innexins.
  • Established a network of innexins involved in ASH-mediated avoidance.

Conclusions:

  • Expands understanding of non-cell-autonomous regulation of ASH neuron sensitivity.
  • Highlights the complex network of innexins fine-tuning behavioral responses.