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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
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Related Experiment Video

Updated: Jun 27, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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Published on: June 8, 2014

LGR4 (GPR48): The Emerging Inter-Bridge in Osteoimmunology.

Wonbong Lim1,2,3,4

  • 1Department of Orthopaedic Surgery, Chosun University, Gwangju 61453, Republic of Korea.

Biomedicines
|March 28, 2025
PubMed
Summary

Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4) may regulate osteoclast differentiation by interacting with RANKL. Further research is needed to explore its role in bone immunology and disease.

Keywords:
leucine-rich repeat-containing G-protein-coupled receptor 4osteoclastsosteoporosisosteoprotegerinreceptor activator of nuclear factor kappa-B ligand

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Area of Science:

  • Osteoimmunology
  • Molecular biology
  • Endocrinology

Background:

  • Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4) is a GPCR involved in bone disease regulation.
  • LGR4 is a potential regulator of nuclear factor-κB ligand (RANKL) in osteoclast differentiation.
  • Existing research lacks a comprehensive understanding of LGR4's function in bone immunology.

Purpose of the Study:

  • To review the molecular characteristics and signaling pathways of LGR4.
  • To elucidate the role of LGR4 in osteoimmunology.
  • To focus on LGR4's interaction with RANKL during osteoclast differentiation and identify research gaps.

Main Methods:

  • Literature review
  • Analysis of signaling pathways
  • Review of molecular characteristics

Main Results:

  • LGR4 exhibits diverse regulatory functions in bone diseases.
  • LGR4 is implicated as a potential regulator of RANKL in osteoclast differentiation.
  • The review identifies gaps in understanding LGR4's role in osteoimmunology.

Conclusions:

  • LGR4 plays a significant role in osteoimmunology, particularly in osteoclast differentiation via RANKL.
  • Further investigation into LGR4's molecular mechanisms and therapeutic applications in bone diseases is warranted.