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The 125I-labelled fibrinogen uptake test in elective hip surgery
Annals of Clinical Research
|January 1, 1985
Summary
The 125I-labelled fibrinogen uptake test effectively screens for deep vein thrombosis after hip surgery. This diagnostic tool shows good sensitivity and specificity, aiding in early detection of potential blood clots.
Area of Science:
- Vascular Surgery
- Diagnostic Imaging
- Nuclear Medicine
Background:
- Deep vein thrombosis (DVT) is a significant risk following major orthopedic procedures like hip surgery.
- Early and accurate detection of DVT is crucial for preventing serious complications such as pulmonary embolism.
Purpose of the Study:
- To evaluate the efficacy of the 125I-labelled fibrinogen uptake test as a non-invasive screening tool for DVT in patients undergoing elective hip operations.
- To compare the diagnostic performance of the fibrinogen uptake test against contrast venography.
Main Methods:
- Prospective study involving 49 patients (97 extremities) undergoing elective hip surgery.
- 125I-labelled fibrinogen uptake tests performed preoperatively and on postoperative days 1, 2, and 4.
- Contrast venography conducted on postoperative day 5 as the reference standard.
Main Results:
- The fibrinogen uptake test demonstrated a sensitivity of 73% and specificity of 85%.
- Positive predictive value was 63% and negative predictive value was 86%, with a correlation coefficient of 55%.
- Most positive uptakes (78%) occurred within 24 hours post-surgery; only 1 in 3 positive femoral uptakes correlated with venographic DVT.
Conclusions:
- The 125I-labelled fibrinogen uptake test is a valuable screening method for DVT in elective hip surgery patients.
- While useful for screening, careful interpretation is needed, especially for positive results in the femoral region, due to potential false positives.