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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.

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Related Experiment Video

Updated: Jun 26, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Does serum Gas6 level change in active uveitis?

Ozgur Cakici1, Omer Faruk Yilmaz2

  • 1Medical Faculty Department of Ophthalmology, Istanbul Medeniyet University, Kadikoy, Istanbul 34700, Turkey.

Therapeutic Advances in Ophthalmology
|March 28, 2025
PubMed
Summary
This summary is machine-generated.

Serum Growth Arrest-Specific Protein 6 (Gas6) levels are elevated during active uveitis. This finding suggests Gas6 may be a useful biomarker for active inflammation in uveitis patients.

Keywords:
Gas6active uveitisinactive uveitis

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Area of Science:

  • Ophthalmology
  • Immunology
  • Biochemistry

Background:

  • Uveitis is a significant cause of visual impairment.
  • Understanding biomarkers for active inflammation is crucial for patient management.

Purpose of the Study:

  • To investigate serum Growth Arrest-Specific Protein 6 (Gas6) levels in active versus inactive uveitis periods.
  • To assess the potential of Gas6 as a biomarker for uveitis activity.

Main Methods:

  • Serum Gas6 levels were measured in 21 uveitis patients during active and inactive phases.
  • Enzyme-Linked Immunosorbent Assay (ELISA) kits were utilized for quantification.

Main Results:

  • Mean Gas6 levels were significantly higher during active uveitis (1.02 ± 0.39 ng/mL) compared to inactive periods (0.71 ± 0.23 ng/mL).
  • Elevated Gas6 levels were observed across various uveitis etiologies.

Conclusions:

  • Serum Gas6 levels are notably elevated in active uveitis, regardless of cause.
  • Further research is warranted to integrate Gas6 into uveitis diagnostic and monitoring protocols.