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Updated: May 7, 2026

EEG Mu Rhythm in Typical and Atypical Development
11:50

EEG Mu Rhythm in Typical and Atypical Development

Published on: April 10, 2014

Oscillometry Phenotypes in Children With Down Syndrome.

Katharine L Hamlington1,2, Emily H Cooper3, Kristine Wolter-Warmerdam4

  • 1Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Pediatric Pulmonology
|March 28, 2025
PubMed
Summary
This summary is machine-generated.

Children with Down syndrome exhibit altered lung function, specifically lower lung compliance, not linked to common co-occurring pulmonary conditions. Further research is needed to understand this lung function phenotype in Down syndrome.

Keywords:
aspirationlung functionpulmonarytracheomalaciatrisomy 21

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Area of Science:

  • Pediatric Pulmonology
  • Genetics and Rare Diseases

Background:

  • Down syndrome is associated with an increased risk of various medical conditions, including pulmonary issues.
  • Understanding lung function in children with Down syndrome is crucial for early diagnosis and management of respiratory complications.

Purpose of the Study:

  • To assess lung function patterns using oscillometry in children with Down syndrome.
  • To investigate associations between lung function and common co-occurring pulmonary diagnoses in this population.

Main Methods:

  • A cross-sectional study involving 50 children with Down syndrome aged 4-18 years.
  • Oscillometry was performed before and after albuterol to measure respiratory resistance (R) and reactance (X).
  • Pulmonary diagnoses (dysphagia, obstructive sleep apnea, tracheomalacia, congenital heart disease) were identified from medical records.

Main Results:

  • Children with Down syndrome showed more negative reactance (X), suggesting lower lung compliance, but normal resistance (R).
  • Elevated frequency dependence of resistance (R5-19) indicated potential airway heterogeneity.
  • Albuterol administration improved lung function, decreasing R and increasing X.

Conclusions:

  • A phenotype of lower lung compliance was observed in 50% of children with Down syndrome.
  • This lung function pattern was not associated with tested co-occurring pulmonary diagnoses.
  • Further investigation is required to elucidate the relationship between this lung phenotype and Down syndrome.