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Updated: Jun 21, 2026

Laparoscopic Oocyte Retrieval and Cryopreservation during Vaginoplasty for Treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome
Published on: May 10, 2022
[Fertility treatment of men with Klinefelter syndrome]
Jens Fedder1,2,3, Anne Skakkebæk4,5,6, Christan Fuglesang S Jensen7
1Center for Andrologi og Fertilitetsklinikken, Odense Universitetshospital.
Abstract:
In this review is described, that men with Klinefelter syndrome (KS) usually have azoospermia, and only a few have obtained paternity with ejaculated sperm. In Denmark, we performed surgery (micro-TESE or subcapsular orchiectomy) in 93 men with KS and obtained testicular sperm in 42% (39). More than ten children are now born, and several couples still have sperm and embryos cryopreserved with the potential to increase the live birth rate further. Since sperm in men with KS originate from cell lines with a normal chromosome number, children born with a father with KS usually have a normal karyotype and are healthy.
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