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Updated: May 6, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 12, 2013

The Sprint to Develop Coronavirus Antivirals.

Michael F T Koehler¹

¹Department of Discovery Chemistry, Genentech Inc., South San Francisco, California 94080, United States.

Journal of Medicinal Chemistry

|March 28, 2025

Summary

This summary is machine-generated.

The discovery of nirmatrelvir (PF-07321332) was rapidly achieved through medicinal chemistry. This led to the Emergency Use Authorization for Paxlovid, enabling swift treatment options.

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Assays for the Identification of Novel Antivirals against Bluetongue Virus

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Published on: October 12, 2013

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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Published on: November 5, 2021

Area of Science:

Medicinal Chemistry
Drug Discovery
Antiviral Therapeutics

Background:

The urgent need for effective antiviral treatments necessitates rapid drug discovery and development.
Preclinical research is a critical phase in identifying and optimizing drug candidates.

Purpose of the Study:

To detail the preclinical research and medicinal chemistry strategies behind the discovery of PF-07321332 (nirmatrelvir).
To highlight the accelerated timeline from project initiation to regulatory authorization.

Main Methods:

Medicinal chemistry optimization of lead compounds.
Structure-based drug design principles.
Integrated preclinical development pathways.

Main Results:

Successful identification and optimization of PF-07321332 (nirmatrelvir) as a potent antiviral agent.
Achieved Emergency Use Authorization (EUA) for Paxlovid in under two years.
Demonstrated the feasibility of rapid drug development through strategic planning and execution.

Conclusions:

Medicinal chemistry is pivotal for accelerating the discovery of novel therapeutics.
Efficient preclinical development can significantly shorten the timeline for drug authorization.
The development of nirmatrelvir exemplifies a successful rapid response to a critical health need.