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Interplay Between Polyphenols and Autophagy: Insights From an Aging Perspective
Alejandro Ponce-Mora1, Nicolle Andrea Salazar1, Alicia Domenech-Bendaña1
1School of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain.
Frontiers in Bioscience (Landmark Edition)
|March 28, 2025
Summary
Polyphenols enhance autophagy, a cellular process crucial for longevity and combating age-related diseases. This review explores their potential in improving healthspan and quality of life for aging populations.
Area of Science:
- Cellular Biology
- Gerontology
- Pharmacology
Background:
- Autophagy, a cellular degradation process, declines with age, contributing to age-related diseases.
- Enhanced autophagy is linked to cellular resilience, longevity, and improved healthspan.
- Polyphenols are natural compounds with potential therapeutic benefits.
Purpose of the Study:
- To review the current literature on the interplay between polyphenols and autophagy.
- To explore the modulatory effects of polyphenols on autophagic pathways in the context of aging.
- To highlight the therapeutic potential of polyphenols in age-related diseases.
Main Methods:
- Systematic literature review of updated research.
- Analysis of studies investigating polyphenol-autophagy interactions.
- Focus on cardiovascular, liver, and kidney diseases.
Main Results:
- Polyphenols modulate autophagic pathways, influencing cellular homeostasis.
- Evidence suggests polyphenols can enhance autophagy, counteracting age-related decline.
- Therapeutic potential demonstrated in cardiovascular, liver, and kidney disease models.
Conclusions:
- Polyphenols show promise as modulators of autophagy to combat age-related diseases.
- Targeting autophagy with polyphenols may improve quality of life in aging populations.
- Further research into polyphenol-autophagy interactions is crucial for longevity medicine.
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