Related Experiment Video
Updated: May 5, 2026
06:06
Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
6.1K
Gout: one year in review 2025
Leonardo Punzi1, Laura Scagnellato2, Paola Galozzi3
1Centre for Gout & Metabolic, Bone and Joint Diseases, Ospedale Civile SS Giovanni e Paolo, Venice, Italy.
Clinical and Experimental Rheumatology
|March 28, 2025
Summary
Gout incidence is rising, with complex causes including genetics and gut health. This review covers the latest research on gout
Area of Science:
- Rheumatology and Molecular Medicine
- Genetics and Genomics
- Gastroenterology
Background:
- Gout incidence has increased significantly, with current management remaining suboptimal.
- The multifactorial etiology of gout involves genetic, environmental, and gut microbiome factors.
- Advances in omics technologies provide deeper insights into hyperuricemia and gout pathogenesis.
Purpose of the Study:
- To present the latest advancements in gout research.
- To cover epidemiology, genetics, molecular mechanisms, diagnostics, and therapeutics for gout.
- To highlight potential novel therapeutic targets arising from comorbidities.
Main Methods:
- Comprehensive literature review of recent studies on gout.
- Analysis of genetic, epigenetic, transcriptomic, proteomic, and metabolomic data.
- Exploration of the interplay between gout and associated systemic diseases.
Main Results:
- Gout pathogenesis is increasingly understood through multi-omics approaches.
- Gut dysbiosis is recognized as a significant contributing factor.
- Comorbidities like cardiovascular, metabolic, and renal diseases offer therapeutic insights.
Conclusions:
- Continued research is crucial for improving gout management.
- Understanding the complex etiology can lead to targeted therapies.
- Novel therapeutic strategies may emerge from studying gout's systemic connections.
Related Concept Videos
01:23Gastritis III: Clinical Manifestations and Management
1.9K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.9K
01:29Chronic Pancreatitis II: Collaborative Care
572
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
572
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
863
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
863
01:30Urinary Tract Calculi III: Medical Management
402
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
402
01:25Urinary Tract Calculi VI: Surgical Management
1.0K
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
1.0K
01:20Cholecystitis
32
Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
32