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Spinal manifestations of diffuse large B-cell lymphoma
Aymeric Amelot1, Louis-Marie Terrier2, Gabrielle Cognacq3
1Department of Neurosurgery, CHRU de Tours, 2 boulevard de Tonnelle, 37000 Tours, France.
Summary
Prognostic factors for spinal diffuse large B-cell lymphoma (DLBCL) metastases are primarily linked to the original disease. Key survival predictors include age, ECOG performance status, and IPI score, guiding treatment decisions.
Area of Science:
- Oncology
- Hematology
- Spinal Oncology
Background:
- Spinal diffuse large B-cell lymphoma (DLBCL) encompasses primary non-Hodgkin's lymphoma (PNHL) and metastases.
- Prognostic factors for spinal DLBCL metastases are not well-established and may differ from other spinal tumors or PNHL.
Purpose of the Study:
- To investigate prognostic factors associated with overall survival (OS) in patients diagnosed with spine DLBCL metastases.
Main Methods:
- Retrospective analysis of 62 patients with spine DLBCL metastases from a cohort of 371 DLBCL patients treated between January 2015 and 2019.
- Collected patient demographics and survival data.
- Utilized Cox multivariate proportional hazard models to identify prognostic factors.
Main Results:
- The median OS for patients with spine DLBCL metastases was 53.0 months.
- Younger age (<40 years), lower ECOG performance status (<2), and lower IPI score (≤2) were associated with longer survival.
- Older age (>80 years) and higher IPI score (>4) were identified as independent poor prognostic factors.
Conclusions:
- Spinal lesions in DLBCL are typically metastatic, unlike primary spinal PNHL.
- Prognostic factors for spinal DLBCL metastases are largely determined by the primary disease characteristics.
- These factors should be considered in the management, including before spinal surgery.
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