Unlocking the potential of plant gums: Bioinformatics-driven insights into green synthesis and applications of...

Plant gums (PGs) are naturally occurring heteropolysaccharides that exude from different plants, typically from their stems, bark, and seeds. They are non-toxic, biodegradable, biocompatible, and cost-effective. PGs are commonly used as emulsifiers, stabilizers, and thickeners in the pharmaceutical, food, and cosmetics industries. Chemically, they are composed of complex sugars, with minor components including proteins, minerals, and flavonoids. Owing to their diverse phytochemical profiles, they have been comprehensively studied over the last couple of decades as reducing, capping, and stabilizing agents for the synthesis of metallic nanoparticles (NPs). Researchers have synthesized various eco-friendly metallic NPs from PGs for potential applications in environmental, industrial, and pharmaceutical domains. This review thoroughly covers the synthesis, characterization techniques, and diverse applications of PG-based metallic NPs. For the first time, using advanced informatics tools like PubChem, ChemSpider, and SwissADME, this study provides novel insights into the molecular interactions and stabilization of PG-based NPs. The review also analyzes the diverse composition of PGs and explores the unique reducing and capping potential of their phytochemicals in the green synthesis of metallic NPs. It also examines the potential drawbacks and proposes possible solutions related to PG-based metallic NP synthesis, along with discussing the future prospects of these nanomaterials.