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Carbohydrate intake and activation of gastric acid secretion decrease gastric estrogen secretion.

Takao Ito1, Yuichi Ozaki2, Atsushi Tanaka2

  • 1Department of Cell Biology and Anatomy, Graduate School of Medicine, Wakayama Medical University, Wakayama, Wakayama, Japan.

Scientific Reports
|March 29, 2025
PubMed
Summary
This summary is machine-generated.

Gastric parietal cells produce estrogen, which lowers blood lipids. Dietary carbohydrates decrease estrogen, while lipids increase it, influencing liver fat production.

Keywords:
EstrogenFatty liverGLP-1InsulinLipogenesisStomach

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Metabolism

Background:

  • Gastric parietal cells secrete estrogen, influenced by blood lipid levels.
  • Estrogen plays a role in reducing blood lipids.
  • Parietal cell energy use for acid and estrogen production links lipid levels and secretion.

Purpose of the Study:

  • Investigate the impact of postprandial changes on gastric estrogen production.
  • Determine the relationship between dietary intake, gastric acid secretion, and estrogen levels.
  • Clarify the role of gastric estrogen in regulating hepatic lipogenesis.

Main Methods:

  • Analysis of blood estrogen and fatty acid (FFA) levels post-meal.
  • Intravenous lipid injections to assess estrogen restoration.
  • Experiments with isolated gastric gland epithelia and hormone manipulation.
  • In vivo studies in rats to examine estrogen levels under varying feeding conditions.

Main Results:

  • Blood estrogen and FFA levels decrease after meals, particularly after carbohydrate intake.
  • Intravenous lipid administration partially restores postprandial estrogen levels.
  • Hormones suppressing gastric acid secretion increase estrogen production in vitro.
  • Suppression of gastric acid secretion elevates blood estrogen in postprandial rats.

Conclusions:

  • Dietary carbohydrates and lipids differentially regulate gastric estrogen production.
  • Carbohydrates decrease, while lipids increase, gastric estrogen synthesis.
  • Gastric estrogen and insulin influence hepatic de novo lipogenesis, suggesting a role in managing dietary fat.
  • Proposed mechanism: Carbohydrates and lipids control gastric estrogen to regulate hepatic lipogenesis.