RNA m⁶A modification meets plant hormones

Plant hormones are essential signalling molecules that control and coordinate diverse physiological processes in plant development and adaptation to ever-fluctuating environments. This hormonal regulation of plant development and environmental responses has recently been shown to extensively involve the most widespread RNA modification, N⁶-methyladenosine (m⁶A). Here we discuss the current understanding of the crosstalk between m⁶A and plant hormones, focusing on their reciprocal regulation, where hormonal signals induce m⁶A reprogramming and m⁶A affects hormone biosynthesis and signalling cascades. We also highlight new insights into how m⁶A contributes to the hormonal control of plant development and stress responses. Furthermore, we discuss future prospects for unveiling the regulatory networks that orchestrate epitranscriptome-hormone interactions and harnessing the related knowledge accrued to enhance crop productivity and resilience in changing environments.