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Control of Therapeutic Activity through Programmed Assembly.

Millicent Dockerill1, Nicolas Winssinger2

  • 1Department of Organic Chemistry, University of Geneva, CH-1211 Geneva.. Millicent.Dockerill@unige.ch.

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Summary
This summary is machine-generated.

This review covers using programmed supramolecular assemblies, like nucleic acid scaffolds, to control therapeutic activity. These systems offer enhanced efficacy and adaptability, with successful in vivo applications shown, particularly in anticoagulation.

Keywords:
CooperativityProgrammed assemblyReversalSupramolecular therapeutics

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Area of Science:

  • Biochemistry and Molecular Biology
  • Materials Science
  • Nanotechnology

Background:

  • Supramolecular systems offer precise control over molecular interactions.
  • Nucleic acids provide versatile scaffolds for constructing complex assemblies.
  • Multivalent interactions are key to enhancing binding affinity and therapeutic outcomes.

Purpose of the Study:

  • To review the programmed assembly of supramolecular systems for controlling therapeutic activity.
  • To explore the use of nucleic acid scaffolds with various ligands.
  • To discuss advancements and challenges in translating these systems for clinical use.

Main Methods:

  • Examination of nucleic acid-based scaffolds for ligand assembly.
  • Analysis of cooperativity principles in multivalent interactions.
  • Review of strand displacement mechanisms for activity control.
  • Highlighting case examples and in vivo studies.

Main Results:

  • Demonstrated programmability of supramolecular assemblies for tailored therapeutic effects.
  • Showcased enhanced binding affinity and therapeutic efficacy through multivalent interactions.
  • Highlighted successful in vivo applications, especially in anticoagulation therapies.

Conclusions:

  • Programmed supramolecular assemblies represent a promising frontier for developing potent and adaptable therapeutics.
  • Nucleic acid-based systems offer a versatile platform for responsive drug delivery and action.
  • Further research is needed to overcome challenges in clinical translation.