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The rodent aging interventions database (RAID): a data visualization tool for all studies reporting rodent lifespan

Maximus V Peto^1,2, Anthony J Floyd¹, Ben Zealley²

¹Long Life Labs, LLC, Buffalo, WY 82834, USA.

|March 29, 2025

Summary

Researchers created the Rodent Aging Interventions Database (RAID) to compile data from studies on lifespan extension in mice and rats. This resource aids future research into aging mechanisms and interventions.

Keywords:

databases life extension longevity mice rats

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Area of Science:

Gerontology
Comparative Biology
Biomedical Research

Background:

Numerous studies have explored interventions to extend rodent lifespans.
Synthesizing findings from these studies is challenging due to the volume of research.
Understanding collective results could reveal fundamental aging mechanisms.

Purpose of the Study:

To create a comprehensive database of rodent lifespan extension studies.
To develop a user-friendly tool for accessing and analyzing this data.
To facilitate future research design and the identification of aging mechanisms.

Main Methods:

Conducted extensive PubMed searches and solicited nominations to identify relevant studies.
Manually extracted key data from 121 unique studies.
Developed a publicly available, web-based software tool for data visualization and filtering.

Main Results:

The Rodent Aging Interventions Database (RAID) currently contains data from 121 studies.
The database includes 212 distinct intervention protocols that extended lifespan in mice or rats.
Data is current as of October 2022, with plans for future updates.

Conclusions:

RAID provides a valuable, centralized resource for researchers studying aging and lifespan extension.
The database simplifies the process of reviewing past interventions and their outcomes.
RAID aims to accelerate the discovery of fundamental aging mechanisms and effective interventions.