Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary involvement in systemic sclerosis (scleroderma).

V D Steen, G R Owens, G J Fino

    Arthritis and Rheumatism
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Natural History of Progressive Systemic Sclerosis (difuse Scleroderma).

    Indian journal of dermatology and venereology·2017
    Same author

    There is a need for new systemic sclerosis subset criteria. A content analytic approach.

    Scandinavian journal of rheumatology·2017
    Same author

    SYSTEMIC SCLEROSIS RELATED CALCINOSIS: PATIENTS PROVIDE WHAT SPECIALISTS WANT TO LEARN.

    The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society·2016
    Same author

    Pulmonary hypertension and interstitial lung disease within PHAROS: impact of extent of fibrosis and pulmonary physiology on cardiac haemodynamic parameters.

    Clinical and experimental rheumatology·2014
    Same author

    Endothelial dysfunction is present only in the microvasculature and microcirculation of early diffuse systemic sclerosis patients.

    Clinical and experimental rheumatology·2014
    Same author

    Recognition of pulmonary hypertension in the rheumatology community: lessons from a Quality Enhancement Research Initiative.

    Clinical and experimental rheumatology·2013
    Same journal

    Proceedings of the Annual Meeting of the American Rheumatism Association.

    Arthritis and rheumatism·2020
    Same journal

    The regional distribution of rheumatologists: what can we do, what should we do?

    Arthritis and rheumatism·2013
    Same journal

    Regional distribution of adult rheumatologists.

    Arthritis and rheumatism·2013
    Same journal

    Clinically significant renal involvement in primary Sjögren's syndrome: clinical presentation and outcome.

    Arthritis and rheumatism·2013
    Same journal

    Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study.

    Arthritis and rheumatism·2013
    Same journal

    Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate.

    Arthritis and rheumatism·2013
    See all related articles

    Systemic sclerosis frequently causes lung disease, especially restrictive lung disease and reduced carbon monoxide diffusion. Smoking worsens pulmonary function in these patients, highlighting the need to discourage smoking.

    Area of Science:

    • Pulmonary Medicine
    • Rheumatology
    • Internal Medicine

    Background:

    • Systemic sclerosis (SSc) is a multisystem autoimmune disease with significant pulmonary involvement.
    • Pulmonary complications are a leading cause of morbidity and mortality in SSc patients.

    Purpose of the Study:

    • To evaluate pulmonary function abnormalities in a cohort of nonsmoking patients with systemic sclerosis.
    • To compare pulmonary involvement in SSc patients with and without CREST syndrome.
    • To assess the impact of smoking on pulmonary function in SSc.

    Main Methods:

    • Pulmonary function testing (PFT) was performed on 165 nonsmoking SSc patients.
    • Patients were categorized based on SSc subtype (CREST vs. diffuse) and presence of restrictive lung disease.

    Related Experiment Videos

  • PFT results were compared between nonsmoking SSc patients and a historical cohort of 137 smoking SSc patients.

    • Main Results:

    • Restrictive lung disease and reduced diffusing capacity for carbon monoxide (DLCO) were common.
    • Pulmonary involvement severity and frequency were similar in CREST and diffuse SSc.
    • Dyspnea correlated with restrictive disease; rales correlated with fibrosis.
    • Nonsmoking patients with restrictive lung disease had a 5-year survival rate of 58%.
    • Smokers exhibited more frequent and severe obstructive changes and lower DLCO compared to nonsmokers.

    Conclusions:

    • Pulmonary function abnormalities are highly prevalent in systemic sclerosis, including CREST syndrome.
    • Smoking exacerbates pulmonary disease in SSc patients, indicating an additive detrimental effect.
    • Pulmonary rehabilitation and smoking cessation are crucial for managing SSc-related lung disease.