Related Experiment Video
Updated: Jul 19, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Investigating the differences in β-Cyclodextrin derivatives / Hyperoside inclusion complexes: Dissolution properties,
Peiran Liu1, Na Gan2, Qinhong Li1
1School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Abstract:
Investigating the structure-activity relationship between β-cyclodextrin derivatives and guest molecules is crucial for the rational design of β-CD inclusion complexes. This study encapsulated hyperoside (HYP) with β-CD, DM-β-CD, and HP-β-CD using a freeze-drying method. Docking studies revealed that the higher binding energy of the HP-β-CD/HYP complex (6.84 kcal/mol) was attributed to the insertion of HYP into the hydrophobic cavity of HP-β-CD. Comparatively, the DM-β-CD/HYP complex exhibited the highest dissolution rate at 93.63 %, surpassing β-CD/HYP (68.10 %), HP-β-CD/HYP (75.05 %), and HYP (60.34 %), which endowed DM-β-CD/HYP with enhanced free radical scavenging activity against DPPH (80.67 %) and ABTS+ (46.32 %). Molecular dynamics (MD) simulations indicated that hydrophobic interactions was instrumental in improving the solubility and bioavailability of HYP, while H-bonding was essential for the stability of the β-CDs. DSC and MD simulations under varying temperatures demonstrated that increased temperature negatively impacted system stability, with H-bonding being critical for the thermal stability.
More Related Videos
07:05Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology
Published on: August 23, 2024
10:03Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis
Published on: August 15, 2025
Related Concept Videos
Stability of Substituted Cyclohexanes
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Stability of Conjugated Dienes
A comparison of the enthalpies of hydrogenation of dienes reveals that conjugated dienes release less heat on hydrogenation, rendering them more stable than their nonconjugated analogs.
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention