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Updated: Jun 23, 2026
Culture Methods to Study Apical-Specific Interactions using Intestinal Organoid Models
Published on: March 23, 2021
Research Advances in the Construction and Application of Intestinal Organoids
Qing Xue Meng1, Hong Yang Yi2, Peng Wang3
1Technology Department, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China;Hebei Provincial Key Laboratory of Systems Biology and Gene Regulation, Central Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
Abstract:
The structure of intestinal tissue is complex. In vitro simulation of intestinal structure and function is important for studying intestinal development and diseases. Recently, organoids have been successfully constructed and they have come to play an important role in biomedical research. Organoids are miniaturized three-dimensional (3D) organs, derived from stem cells, which mimic the structure, cell types, and physiological functions of an organ, making them robust models for biomedical research. Intestinal organoids are 3D micro-organs derived from intestinal stem cells or pluripotent stem cells that can successfully simulate the complex structure and function of the intestine, thereby providing a valuable platform for intestinal development and disease research. In this article, we review the latest progress in the construction and application of intestinal organoids.
