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Updated: Jul 11, 2026
06:43
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
Published on: December 7, 2013
Sex-Specific Association between HO-1 (GT)n Promoter Polymorphism and Large-Artery Atherosclerosis Stroke
Jintao Li1,2, Junting Chen3, Jia Wen2
1Department of Neurology and Stroke Center, The 10th Affiliate Hospital, Southern Medical University.
Journal of Atherosclerosis and Thrombosis
|March 30, 2025
Summary
The heme oxygenase-1 (HO-1) gene
Area of Science:
- Genetics and Cardiovascular Disease
- Oxidative Stress Mechanisms
- Atherosclerosis Pathogenesis
Background:
- Oxidative stress is integral to atherosclerosis development.
- Heme oxygenase-1 (HO-1) induction combats reactive oxygen species toxicity.
- HO-1 induction is modulated by its promoter (GT)n repeat length.
Purpose of the Study:
- To investigate the association between HO-1 gene (GT)n polymorphism and large-artery atherosclerotic (LAA) stroke.
- To explore potential sex-specific differences in this association.
Main Methods:
- Case-control study recruiting stroke patients and matched non-stroke controls.
- HO-1 (GT)n genotypes determined from leukocyte DNA.
- Polymorphism classified as short (S), medium (M), or long (L); multivariable logistic regression used.
Main Results:
- No significant difference in HO-1 (GT)n genotypes between overall stroke and non-stroke populations.
- S/S genotype was less frequent in LAA stroke patients compared to non-LAA stroke patients (7.08% vs. 21.78%).
- Non-SS genotypes increased LAA risk (OR 3.35). The S/S genotype showed a protective effect in men (OR 5.50) but not in women (OR 1.60).
Conclusions:
- Short (GT)n variants in the HO-1 gene may offer protection against LAA stroke, particularly in men.
- This protective association was not significant in women, suggesting a sex-specific effect.
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