Related Experiment Video
Updated: Jul 16, 2026
07:40
Digital Analysis of Immunostaining of ZW10 Interacting Protein in Human Lung Tissues
Published on: May 1, 2019
5.4K
Digital Pathology in Real-Life Conditions for Daily Cytopathological Diagnosis: A Feasibility Study
Ranya Soufan1, Alicia Larive2, Irène Villa3
1Gustave Roussy, Département de Biologie et Pathologie Médicales, Villejuif, France.
Acta Cytologica
|March 30, 2025
Summary
Digital pathology using whole-slide imaging (WSI) shows high concordance with traditional light microscopy (LM) for cytopathological diagnosis. This study confirms WSI
Area of Science:
- Pathology
- Digital Health
- Cytopathology
Background:
- Digital pathology adoption is increasing for diagnostic applications.
- Whole-slide imaging (WSI) offers a digital alternative to traditional light microscopy (LM).
Purpose of the Study:
- To assess the feasibility of cytopathological diagnosis using WSI in routine practice.
- To compare diagnostic accuracy between WSI and LM.
Main Methods:
- 110 non-gynecologic cytopathology cases were diagnosed via LM and then by WSI by the same pathologist.
- Pathologists were blinded to LM diagnoses but had clinical information.
- WSI diagnoses were compared to original LM diagnoses for concordance.
Main Results:
- An overall concordance rate of 87.3% was observed between WSI and LM diagnoses.
- Excluding thyroid cases, the concordance rate increased to 90.5%.
- Intra-observer agreement was lowest for thyroid fine-needle aspiration cytology.
Conclusions:
- Primary cytological diagnosis is feasible using a digital system.
- WSI demonstrates high diagnostic accuracy comparable to LM.
- Digital pathology systems can be effectively integrated into daily practice.
