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Related Concept Videos

Integration of Synaptic Events01:28

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Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability...
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Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
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A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the...
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Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
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Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
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Subthreshold variability of neuronal populations driven by synchronous synaptic inputs.

Logan A Becker1,2, François Baccelli3,4,5, Thibaud Taillefumier1,2,3

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Neuronal activity shows significant variability. This study reveals that weak synchrony in neural spiking explains voltage fluctuations and covariability, highlighting synchrony

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Neuronal responses exhibit significant spiking variability even with identical stimuli.
  • Subthreshold membrane voltage fluctuations also display considerable variability in vivo.
  • Prior work linked these voltage fluctuations to weak, non-zero spiking synchrony.

Purpose of the Study:

  • To investigate if spiking synchrony can explain additional statistical features of neural activity, specifically voltage covariability and skewness.
  • To analyze the role of synchrony in shaping the statistical properties of neuronal voltage.
  • To confirm synchrony as a driver of cortical variability.

Main Methods:

  • Generalized moment analysis of conductance-based neuron models.
  • Input drives modeled as correlated jump processes.
  • Application of fixed-point techniques from queuing theory for stationary activity analysis.

Main Results:

  • Weak but non-zero synchrony consistently explains experimentally reported voltage covariance.
  • Synchrony also accounts for observed voltage skewness in neural activity.
  • The findings align with experimentally measured spiking correlations.

Conclusions:

  • Spiking synchrony is a primary driver of cortical variability.
  • Physiological neural activity, particularly in the spontaneous regime, emerges as a population-level phenomenon.
  • The study reinforces the link between spiking synchrony and subthreshold voltage dynamics.