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Updated: May 16, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Tuning Tetrazine Substituents to Enhance Vinyltetrazine Labeling Performance

Xinxin Liang1, Jie Li1, Xinyu He1

  • 1Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province and Frontiers Science Center for Disease Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.

Chembiochem : a European Journal of Chemical Biology
|March 31, 2025
PubMed
Summary

Vinyltetrazine, a thiol-specific labeling reagent, enables dual-modality imaging and improves peptide drug delivery. Modifications to vinyltetrazine enhance labeling efficiency, kinetics, and stability for advanced applications.

Keywords:
bioorthogonalscysteine labelingspeptide modificationstetrazines

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