Mechanochemical Functionalization of Heterocycles by C-H Activation: An Update
Mainak Banerjee1, Abboy Chatterjee1, Shaurya Aneja1
1Department of Chemistry, Birla Institute of Technology and Science Pilani, KK Birla Goa Campus, NH 17B Bypass Road, Zuarinagar, Goa, 403726, India.
Abstract:
The mechanochemical C-H activation of heterocycles presents a sustainable, solvent-free alternative to the traditional solution-phase synthesis. Heterocycles are fundamental molecular scaffolds in medicinal chemistry and drug discovery. This review highlights recent advances in mechanochemical methods for metal-catalyzed and metal-free C-H functionalization/derivatization, including arylation, alkenylation, acylation, borylation, trifluoromethylation, etc., applied across various heterocyclic compounds. Emphasizing green aspects, this synopsis provides a comprehensive overview of mechanochemical innovations, their unique features and advantages, transformative potential for ecofriendly synthesis, and future prospects of sustainability.
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