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Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional
Maria Picó-Pérez1, Beatriz Couto2, Ricardo Magalhães3
1Life and Health Sciences Research Institute (ICVS), University of Minho; Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I; b8467@med.uminho.pt.
Journal of Visualized Experiments : Jove
|March 31, 2025
Summary
This study investigates emotion regulation deficits in obsessive-compulsive disorder (OCD) using functional magnetic resonance imaging (fMRI). It aims to uncover the neural basis of cognitive reappraisal difficulties in OCD patients.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- Obsessive-compulsive disorder (OCD) is linked to heightened limbic and orbitofrontal activity during negative emotional states.
- Impaired emotion regulation skills may contribute to OCD pathophysiology.
- Cognitive reappraisal, a key emotion regulation strategy, is well-studied in the general population but poorly understood in OCD.
Purpose of the Study:
- To investigate the neural correlates of deliberate emotion regulation, specifically cognitive reappraisal, in patients with OCD.
- To compare emotion regulation abilities and associated brain activity between OCD patients and a matched control group.
- To explore potential deficits in emotion regulation strategies within the OCD population.
Main Methods:
- Utilizing functional magnetic resonance imaging (fMRI) to examine brain activity during a cognitive reappraisal task.
- Employing both task-based activation and functional connectivity analyses.
- Collecting behavioral data to complement neuroimaging findings.
Main Results:
- The protocol is designed to identify differences in neural activation and connectivity patterns during emotion regulation between OCD patients and controls.
- Expected findings will elucidate the neurobiological underpinnings of emotion (dys)regulation in OCD.
- Behavioral data will provide insights into the efficacy of cognitive reappraisal in OCD.
Conclusions:
- This research protocol offers a comprehensive approach to understanding emotion regulation deficits in OCD.
- Findings are expected to advance knowledge of the neural mechanisms underlying emotion dysregulation in OCD.
- The protocol's adaptability may facilitate research into emotion regulation in other psychiatric disorders.
