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Updated: May 16, 2025

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Scaffold-Adaptive P450 Enzymes Balance Substrate Promiscuity with Catalytic Specificity in Brassicicene Biosynthesis

Zhe Chen1, Wenling Yuan1, Fengli Li1

  • 1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China.

Organic Letters
|March 31, 2025
PubMed
Summary

This study explores the flexibility of two enzymes, AbnK and AbnG, in creating brassicicenes. Their actions on different molecular structures reveal insights into natural product diversity and chemoenzymatic synthesis.

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