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[One case of recurrent infection with chlamydia psittaci pneumonia]

H Y Zhou1, J Zhang1, D D Weng2

  • 1Department of Respiratory and Critical Care Medicine, Yuyao People's Hospital, Yuyao 315400, China.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases
|March 31, 2025
PubMed

Insights

This study details a patient with recurrent Chlamydia psittaci pneumonia, successfully diagnosed using advanced sequencing methods. Prompt treatment with tetracycline antibiotics led to a swift recovery, highlighting effective management strategies for this zoonotic infection.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Microbiology

Background:

  • Recurrent Chlamydia psittaci pneumonia is a rare but serious zoonotic infection.
  • Exposure to infected live poultry is a common risk factor.
  • Clinical presentation can mimic other respiratory illnesses, complicating diagnosis.

Purpose of the Study:

  • To analyze the clinical course and diagnostic approach for a patient with recurrent Chlamydia psittaci pneumonia.
  • To evaluate the efficacy of metagenomic and targeted next-generation sequencing in diagnosing the infection.
  • To assess the treatment outcomes with tetracycline-based therapy.

Main Methods:

  • Case study analysis of a patient with recurrent pneumonia.
  • Detection of Chlamydia psittaci using metagenomic next-generation sequencing (mNGS) and pathogen targeted next-generation sequencing (tNGS) on bronchoalveolar lavage fluid.
  • Clinical assessment, chest CT imaging, and treatment monitoring.

Main Results:

  • The patient experienced recurrent Chlamydia psittaci pneumonia within seven months, presenting with fever, cough, and respiratory failure.
  • Chest CT revealed lobar consolidation, ground-glass shadows, and pleural effusion.
  • mNGS and tNGS facilitated early and accurate diagnosis of both infectious episodes.
  • Treatment with tetracycline antibiotics resulted in rapid clinical improvement.

Conclusions:

  • Early diagnosis of Chlamydia psittaci pneumonia is crucial for effective management.
  • Next-generation sequencing techniques (mNGS and tNGS) are valuable tools for identifying this pathogen.
  • Tetracycline-based regimens are effective for treating Chlamydia psittaci pneumonia.
Keywords:
Bronchoalveolar lavageChlamydial pneumoniaMetagenomic next-generation sequencingPathogen targeted next-generation sequencingPsittacosis

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