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  1. Home
  2. Risk Factors For Progression To Type 2 Diabetes In Prediabetes: A Systematic Review And Meta-analysis.
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  2. Risk Factors For Progression To Type 2 Diabetes In Prediabetes: A Systematic Review And Meta-analysis.

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Risk factors for progression to type 2 diabetes in prediabetes: a systematic review and meta-analysis.

Shengying Hu1, Wenting Ji2, Yizhu Zhang1

  • 1School of Nursing, Peking University, Beijing, 100191, China.

BMC Public Health
|April 1, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Prediabetes progression to type 2 diabetes mellitus (T2DM) is linked to numerous risk factors. A high Fatty Liver Index is a significant predictor, alongside age, BMI, lifestyle, and comorbidities.

Keywords:
Meta-analysisPrediabetesRisk factorsSystematic ReviewType 2 diabetes mellitus

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Area of Science:

  • Endocrinology and Metabolism
  • Public Health
  • Epidemiology

Background:

  • Prediabetes represents the earliest stage of glycemic dysregulation.
  • Identifying and managing risk factors is crucial for delaying progression to type 2 diabetes mellitus (T2DM).
  • A comprehensive summary of T2DM progression risk factors from prediabetes is needed.

Purpose of the Study:

  • To systematically evaluate risk factors for prediabetes progression to T2DM.
  • To provide a theoretical basis for early recognition and intervention strategies.
  • To identify key predictors, such as the Fatty Liver Index, for T2DM development.

Main Methods:

  • Systematic literature search across major databases (PubMed, Web of Science, Embase, etc.) up to February 15, 2024.
  • Inclusion of cohort studies investigating risk factors for T2DM progression in prediabetes.
  • Meta-analysis conducted using STATA 17.0 on 59 medium to high-quality studies.
  • Main Results:

    • Identified risk factors across sociodemographic (age, male sex, family history, high BMI, waist circumference, waist-to-hip ratio), lifestyle (lack of exercise, smoking), psychosocial (anxiety, depression), and comorbidity categories (hypertension, high triglycerides, high cholesterol, fatty liver index, low HDL-C, high blood glucose).
    • The Fatty Liver Index showed a significant association (OR = 6.14, 95% CI [5.22, 7.22]).
    • Moderate physical activity was identified as a protective factor (OR = 0.24, 95% CI [0.09, 0.67]).

    Conclusions:

    • Age, male sex, family history, high BMI, unhealthy lifestyle, anxiety, depression, hypertension, high triglycerides, and a high Fatty Liver Index are significant risk factors for T2DM progression.
    • Moderate physical activity and low HDL-C levels are protective factors.
    • Further research should focus on increasing follow-up duration and refining diagnostic criteria for prediabetes.