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Related Concept Videos

Tissues01:18

Tissues

79.4K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
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Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.4K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Related Experiment Video

Updated: May 16, 2025

Creation of Abdominal Adhesions in Mice
06:44

Creation of Abdominal Adhesions in Mice

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Tissue adhesion after surgical interventions (Review).

Malin C K Sturm1, Alexander Abazid2, Matthias B Stope1

  • 1Department of Gynecology and Gynecological Oncology, University Hospital Bonn, D-53127 Bonn, Germany.

Experimental and Therapeutic Medicine
|April 1, 2025
PubMed
Summary

Postoperative tissue adhesions are a frequent surgical complication causing pain and dysfunction. Current treatment options for these adhesions are limited, highlighting a significant unmet clinical need.

Keywords:
adhesion prophylaxisadhesion therapyperitoneumpostoperative complicationssurgery

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Area of Science:

  • Surgical Complications
  • Postoperative Care
  • Medical Economics

Background:

  • Tissue adhesion is a prevalent postoperative complication across all surgical fields.
  • Pelvic surgeries frequently result in adhesions, detected in over half of patients during second-look procedures.
  • Adhesions can lead to severe symptoms including pain, nausea, ileus, and reproductive dysfunction, alongside significant healthcare costs.

Purpose of the Study:

  • To highlight the clinical and economic burden of postoperative tissue adhesions.
  • To underscore the limitations in current adhesion prophylaxis and treatment options.
  • To emphasize the need for improved strategies in managing surgical adhesions.

Main Methods:

  • Review of existing literature on postoperative tissue adhesion.
  • Analysis of clinical data regarding adhesion-related complications and patient outcomes.
  • Examination of healthcare expenditures associated with adhesion management.

Main Results:

  • Adhesions are found in a substantial number of patients post-surgery, particularly after pelvic procedures.
  • Symptomatic adhesions contribute to significant patient morbidity and increased healthcare costs.
  • Undetected adhesions complicate future surgeries, leading to delays and additional risks.

Conclusions:

  • Postoperative tissue adhesions represent a major surgical and health economic challenge.
  • The current lack of effective prophylaxis and treatment options necessitates further research and development.
  • Addressing the burden of adhesions is crucial for improving patient outcomes and reducing healthcare expenditure.