Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A novel SadP-scFv UCHT1 lectibody activates T cells and mediates lysis of Burkitt's lymphoma cells.

RSC chemical biology·2025

Same author

Update and New Implementation of the MIRAGE Reporting Guidelines for Mass Spectrometry Experiments in Glycoscience.

Molecular & cellular proteomics : MCP·2025

Same author

The Parkinson's Disease Drug Tolcapone and Analogues are Potent Glycomimetic Lectin Inhibitors of Pseudomonas aeruginosa LecA.

Angewandte Chemie (International ed. in English)·2025

Same author

Antiadhesive glycoconjugate metal complexes targeting pathogens <i>Pseudomonas aeruginosa</i> and <i>Candida albicans</i>.

Organic & biomolecular chemistry·2025

Same author

Microbial Lectin-Targeting Mucus: A Glycobioinformatic Approach.

Methods in molecular biology (Clifton, N.J.)·2025

Same author

Bacterial lectins: multifunctional tools in pathogenesis and possible drug targets.

Trends in microbiology·2025

Same journal

Understanding glycan structure and function through artificial intelligence.

BBA advances·2026

Same journal

Role of recombinant S100A13 expression in regulating mitochondrial fission and fusion in lung epithelial cells.

BBA advances·2026

Same journal

Lysosomal membrane permeabilization is involved in CYP2E1-induced apoptosis in hepatocellular carcinoma cells.

BBA advances·2026

Same journal

miR-765 induces angiogenesis by inhibiting dipeptidyl peptidase 4 and increasing fibroblast growth factor 2.

BBA advances·2026

Same journal

Drying parameters and aging modulate protective properties of vitrified trehalose.

BBA advances·2026

Same journal

AGTRAP mediates exosome-driven communication between cancer cells and macrophages via p38 MAPK pathway to promote hepatocellular carcinoma.

BBA advances·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 16, 2025

Author Spotlight: Advancing Protein Glycosylation Research Using a Fully Automated System

Author Spotlight: Advancing Protein Glycosylation Research Using a Fully Automated System

Published on: June 28, 2024

Tools for structural lectinomics: From structures to lectomes.

Frédérique Lisacek^1,2, Boris Schnider^1,2, Anne Imberty³

¹SIB Swiss Institute of Bioinformatics CH-1227 Geneva, Switzerland.

|April 1, 2025

Summary

This summary is machine-generated.

Lectins are proteins crucial for cell communication and disease. Advances in structural data and AI now enable better characterization and prediction of lectin functions and interactions.

Keywords:

AI Bioinformatics Carbohydrate-binding Lectin Modelling Prediction method Structural biology

More Related Videos

A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples

A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples

Published on: October 1, 2009

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

Related Experiment Videos

Last Updated: May 16, 2025

Author Spotlight: Advancing Protein Glycosylation Research Using a Fully Automated System

Author Spotlight: Advancing Protein Glycosylation Research Using a Fully Automated System

Published on: June 28, 2024

A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples

A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples

Published on: October 1, 2009

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

Area of Science:

Biochemistry and Molecular Biology
Structural Biology
Bioinformatics

Background:

Lectins are proteins that bind carbohydrates (glycans) and are involved in essential biological processes.
Dysfunctional lectin activity is implicated in various diseases, including infections, chronic conditions, and cancer.
Understanding lectin structure and function is key to deciphering cell-cell communication.

Purpose of the Study:

To review current methods for determining lectin three-dimensional (3D) structures.
To summarize available data on lectin 3D structures and their interactions.
To explore the use of structural and bioinformatics data for lectin classification and predicting binding specificity.

Main Methods:

Review of experimental techniques for protein structure determination (e.g., X-ray crystallography, NMR spectroscopy).
Analysis of publicly available structural databases (e.g., PDB).
Integration of bioinformatics tools for data analysis and prediction.

Main Results:

Significant advancements in obtaining lectin 3D structures have been achieved.
Extensive structural data for numerous lectins and their interactions are now accessible.
Current knowledge facilitates lectin classification based on structural and functional properties.

Conclusions:

The combination of structural data and bioinformatics tools is essential for advancing lectin research.
Predicting lectin binding specificity is becoming increasingly feasible with these integrated approaches.
Further research into lectin structures and interactions will enhance understanding of cellular processes and disease mechanisms.